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BioHOS

Analysis for the determination of a biologic drug’s higher order structure

Mnova BioHOS is designed for the NMR analysis of biotherapeutics, like monoclonal antibodies. 2D NMR spectra of reference samples are compared with that of each test sample using a fingerprinting, or spectral similarity determination.

Licenses of Mnova NMR and Chemometrics are required to use Mnova BioHOS

 

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Designed in collaboration with Bruker BioSpin, Mnova BioHOS capabilities will support your analytical needs for the Quality Assessment of Biologic drugs using 2D NMR spectral data.

Designed in collaboration with Bruker BioSpin, Mnova BioHOS capabilities will support your analytical needs for the Quality Assessment of Biologic drugs using 2D NMR spectral data.

BioHOS

Highlights

Mnova BioHOS – NIST mAb data

Includes several published and accepted methods to conduct analysis:

  – Principal Component Analysis, PCA – unsupervised chemometrics

  – Easy Comparability of Higher Order Structure, ECHOS – simple representation of spectral differences

  – Combined Chemical Shift Difference, CCSD – number that represents the shifts in peak positions

  – 1D Profile uses 1D NMR spectra to detect small spectral changes and carry out a statistical analysis on evaluations

Quality Assessment of Biologic drugs using 2D NMR spectral data

Capitalise on a powerful, intuitive user interface

Excellent, fundamental capabilities and algorithms

Interactivity between the analysis results and spectral data

Similarity assessment between a drug and its reference material, allowing rapid pass / fail evaluations

MSChrom

Features

  •       ? Pairwise intensity comparisons of points with the same coordinates in the reference – and test spectra

          ? A regression line is computed for the scatter plot of points. Manual and automatic noise cancellation

          ? Adjust threshold for residuals

  •       Selected peaks in the reference spectrum are matched with peaks in the test data and the Combined Chemical Shift Difference (average and per peak pair) is calculated

          Average CCSD for each test spectrum, to rank them by similarity with the reference

          Plot CCSD values and amplitude ratio per pair of peaks and inspect relevant spectral regions with just one click

  •       Dedicated features for data management including: adjusting preparation parameters, binning to reduce data size, conducting integrity checks, filtering, normalizing and scaling

          PCA results available in interactive plots always connected to the spectra

          Explained Variance, Influence, Scores and PCA loadings plot templates available

  • This uses 1D NMR spectra. Small spectral changes are detected and a statistical analysis performed on evaluations.

          Typically uses 1D 1H spectra

          Small differences are quantified

          Statistically treat spectra for many spectra

BioHOS

Academic, Government & Industrial

  •      ✯? NMR Quality Assessment of biologic drugs
  •      ✯? Similarity assessment of generic biologic drugs
  •      ✯? Suitable for Pharmaceutical companies, CROs and academic organizations

BioHOS

Contact us

    ✈:No. 377, Nanjing Road, Shibei District, Qingdao, Shandong

    ☏:0532-83818797 / 18561885100

    ✉:changzhu_ ji@tlwb.com.cn

          shuochao_dai@tlwb.com.cn

          support@tlwb.com.cn

 

Learn more

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